RESUMO
A carrier design strategy of hydrogen bonding enhanced drug-carrier interaction is developed to prepare a polymeric nanomedicine with high drug loading content and superb loading efficiency. Moreover, a morphology transition from spherical to cylindrical micelles is observed upon increasing drug loading content, which can open up a new way for controlling the morphology of the polymeric nanomedicine.
Assuntos
Portadores de Fármacos , Ligação de Hidrogênio , Polímeros , Portadores de Fármacos/química , Polímeros/química , Micelas , Liberação Controlada de FármacosRESUMO
A photo-responsive host-guest molecular recognition between a cationic pillar[6]arene host and an arylazopyrazole derived guest was established. Based on this novel recognition motif, a photo-controllable supra-amphiphile was constructed. The spontaneous aggregation can be reversibly controlled by irradiation with UV (365 nm) and green light (520 nm), leading to a switch between spherical nanoparticles and vesicle-like aggregates.